Mesaconitine
نویسندگان
چکیده
The title compound, (1α,3α,6α,14α,15α,16β)-3,8,13,14,15-penta-hydr-oxy-1,6,16-trimeth-oxy-4-methoxy-methyl-20-methyl-acon-itan-8,14-diyl 8-acetate 14-benzoate, C(33)H(45)NO(11), a C(19) diterpenoid alkaloid, obtained from the roots of Aconitum kusnezoffii, has been crystallographically characterized in this study. Rings A, B and E have chair conformations, rings C and F display envelope conformations, and ring D adopts a boat conformation. There are inter- and intra-molecular O-H⋯O hydrogen bonds, the latter resulting in the formation of a non-planar seven-membered ring. The inter-molecular inter-actions link the mol-ecules into a two-dimensional network.
منابع مشابه
[Percutaneous absorption of aconitine and mesaconitine in extracts of Radix Aconitum kusnezoffii].
OBJECTIVE This study was conducted to evaluate the percutaneous absorption of aconitine and mesaconitine in extracts of Radix Aconitum kusnezoffii. METHODS The extracts of Radix Aconitum kusnezoffii were collected by using Franz diffusion cells after permeation through the skin of rats. Then rate constants of skin permeation of aconitine and mesaconitine were determined by high-performance li...
متن کاملEffects of Culture Temperature on Microtuber Formation of Aconitum Carmichaelii Debx. and Aconitine- Type Alkaloid Contents
SHIPING c., SHAN S.], TANAKA H. and SHOYAMA Y. Effects of culture temperature on microtuber formation of Aconitum carmichaelii Debx. and aconitine -type alkaloid contents BIOTRONICS 27, 15-20, 1998. The clonally propagated Aconitum carmichaelii Debx. was used for the investigation of microtubering. The rooting condition of propagated shoots affected the establishment of transplantation to soil ...
متن کاملNeutral Fragment Filtering for Rapid Identification of New Diester-Diterpenoid Alkaloids in Roots of Aconitum carmichaeli by Ultra-High-Pressure Liquid Chromatography Coupled with Linear Ion Trap-Orbitrap Mass Spectrometry
A rapid and effective method was developed for separation and identification of diester-diterpenoid alkaloids (DDA) in the roots of Aconitum carmichaeli by ultra-high-pressure liquid chromatography coupled with high resolution LTQ-Orbitrap tandem mass spectrometry (UHPLC-LTQ-Orbitrap-MS(n)). According to accurate mass measurement and the characteristic neutral loss filtering strategy, a total o...
متن کاملIdentification of Potential Biomarkers from Aconitum carmichaelii, a Traditional Chinese Medicine, Using a Metabolomic Approach.
Despite their well-known toxicity, Aconitum species are important traditional medicines worldwide. Aconitum carmichaelii, known in Chinese as (fuzi), is an officially recognized traditional Chinese medicine with characteristic analgesic and anti-inflammatory activities, whose principal pharmacological ingredients are considered as aconitine-type diterpene alkaloids. Notwithstanding the long-rec...
متن کاملThe Influence of Tetrodotoxin Erects of Aconitine in vivo on the Toxic
OHNO, Y., CHIBA, S., UCHIGASAKI, S., UCHIMA, E., NAGAMORI, H., MIZUGAKI, M., OHYAMA, Y., KIMURA, K. and SUZUKI, Y. The Influence of Tetrodotoxin on the Toxic Effects of Aconitine in vivo. Tohoku J. Exp. Med., 1992, 167 (2), 155158 Both aconite toxins (aconitine, mesaconitine, and hypaconitine) and a pufferfish toxin (tetrodotoxin, TTX) were detected in the blood of a legal autopsy case. In orde...
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عنوان ژورنال:
دوره 64 شماره
صفحات -
تاریخ انتشار 2008